Cui D, Arima M, Hirayama T, Ikeda E*: Hypoxia-induced disruption of neural vascular barrier is mediated by the intracellular induction of Fe(II) ion.  Exp Cell Res 379:166-171, 2019. doi: 10.1016/j.yexcr.2019.04.003. Epub 2019 Apr 7 [*corresponding author]

Hisano T, Cui D, Harada K, Kimura T, Mishima K, Ikeda E*: Overexpression of Runt-related transcription factor-1 at invasive front in oral squamous cell carcinoma is associated with lymph node metastasis and poor prognosis. The Bulletin of the Yamaguchi Medical School (in press). [*corresponding author]

Kimura T, Cui D, Kawano H, Yoshitomi-Sakamoto C, Takakura N, Ikeda E*: Induced expression of GINS complex is an essential step for reactivation of quiescent stem-like tumor cells within the peri-necrotic niche in human glioblastoma. J Cancer Res Clin Oncol 145:363-371, 2019. doi: 10.1007/s00432-018-2797-z. Epub 2018 Nov 21  [*corresponding author]


Nawata T, Kubo M, Kobayashi S, Nakada N, Maeda M, Cui D, Kimura T, Ikeda E, Yano M: Mucormycete Infiltration in the Cardiac Conduction System.  Can J Cardiol 34:92.e9-92.e10, 2018. doi:10.1016/j.cjca.2017.10.002

Onoda H, Kimura T, Tao H, Okabe K, Matsumoto T, Ikeda E: Air bronchogram in pleomorphic carcinoma of the lung is associated with favorable prognosis. Thorac Cancer 9:718-725, 2018. doi: 10.1111/1759-7714.12638. Epub 2018 Apr 6


Nishimoto T, Nomura S, Fukano R, Kimura T, Ikeda E, Suzuki M: A primary extradural malignant rhabdoid tumor at the craniovertebral junction in a 3-year-old boy.  Childs Nerv Syst 2017. doi: 10.1007/s00381-017-3631-7

Nishihara H, Omoto M, Takao M, Higuchi Y, Koga M, Kawai M, Kawano H, Ikeda E, Takashima H, Kanda T: Autopsy case of the C12orf65 mutation in a patient with signs of mitochondrial dysfunction.  Neurol Gene. 3:e171, 2017. doi: 10.1212/NXG.0000000000000171


Arima M, Cui D, Kimura T, Sonoda KH, Ishibashi T, Matsuda S, Ikeda E*: Basigin can be a therapeutic target to restore the retinal vascular barrier function in the mouse model of diabetic retinopathy.  Sci Rep 6, 38445; doi: 10.1038/srep38445, 2016  [*corresponding author]

Kawano H, Kimura T*, Kikuchi N, Ishii A, Ikeda E: Stroma-poor Warthin tumor with significant oncocytic hyperplasia: case presentation and considerations regarding its histogenesis.  Rom J Morphol Embryol 57:585-590, 2016  [*corresponding author]

Ideguchi M, Nishizaki T, Ikeda N, Nakano S, Okamura T, Fujii N, Kimura T, Ikeda E: Metastatic cerebellar tumor of papillary thyroid carcinoma mimicking cerebellar hemangioblastoma. See comment in PubMed Commons belowSpringerplus 5:916, 2016. doi: 10.1186/s40064-016-2551-4

Harada K, Ferdous T, Cui D, Kuramitsu Y, Matsumoto T, Ikeda E, Okano H, Ueyama Y: Induction of artificial cancer stem cells from tongue cancer cells by defined reprogramming factors.  BMC Cancer 16:548, 2016. doi: 10.1186/s12885-016-2416-9

Sugai K, Fukuzawa R, Shofuda T, Fukusumi H, Kawabata S, Nishiyama Y, Higuchi Y, Kawai K, Isoda M, Kanematsu D, Hashimoto-Tamaoki T, Kohyama J, Iwanami A, Suemizu H, Ikeda E, Matsumoto M, Kanemura Y, Nakamura M, Okano H: Pathological classification of human iPSC-derived neural stem/progenitor cells towards safety assessment of transplantation therapy for CNS diseases.  Mol Brain 9:85, 2016. doi: 10.1186/s13041-016-0265-8

Miyawaki S, Kawamura Y, Oiwa Y, Shimizu A, Hachiya T, Bono H, Koya I, Okada Y, Kimura T, Tsuchiya Y, Suzuki S, Onishi N, Kuzumaki N, Matsuzaki Y, Narita M, Ikeda E, Okanoya K, Seino K, Saya H, Okano H, Miura K: Tumour resistance in induced pluripotent stem cells derived from naked mole-rats.  Nature Commun 7:11471, 2016  doi: 10.1038/ncomms11471

Ohtomo-Oda R, Komatsu S, Mori T, Sekine S, Hirajima S, Yoshimoto S, Kanai Y, Otsuji E, Ikeda E, Tsuda H: SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas.  Hum Pathol 49:145-155, 2016

Ishii A, Kimura T*, Sadahiro H, Kawano H, Takubo K, Suzuki M, Ikeda E*: Histological characterization of the tumorigenic "peri-necrotic niche" harboring quiescent stem-like tumor cells in glioblastoma.  PLoS ONE 11:e0147366, 2016. doi: 10.1371/journal.pone.0147366.  [*corresponding author]

Sugimoto K, Ideguchi M, Kimura T, Kajiwara K, Imoto H, Sadahiro H, Ishii A, Kawano H, Ikeda E, Suzuki M: Epithelioid/rhabdoid glioblastoma: a highly aggressive subtype of glioblastoma.  Brain Tumor Pathol 33:137-146, 2016

Kawano H, Ishii A, Kimura T, Takahashi T, Hironaka H, Kawano M, Yamaguchi M, Oishi K, Kubo M, Matsui S, Notohara K, Ikeda E*: IgG4-related disease manifesting the gastric wall thickening.  Pathol Int 66:23-28, 2016  [*corresponding author]


Cui D, Arima M, Takubo K, Kimura T, Horiuchi K, Minagawa T, Matsuda S, Ikeda E*
: ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function.  Sci Rep 5, 12796; doi: 10.1038/srep12796, 2015
 [*corresponding author]

Kawano H, Kimura T*
, Iwata K, Furukawa M, Nomura S, Ishii A, Tanaka S, Hoshii Y, Suzuki M, Ikeda E: Atypical extraventricular neurocytoma in a 3-year-old girl: case report with radiological-pathological correlation.  Childs Nerv Syst 31:1189-1193, 2015  [*corresponding author]

Sano Y, Nakano Y, Omoto M, Takao M, Ikeda E, Oga A, Nakamichi K, Saijo M, Maoka T, Sano H, Kawai M, Kanda T: Rituximab-associated Progressive Multifocal Leukoencephalopathy Derived from Non-Hodgkin Lymphoma: Neuropathological Findings and Results of Mefloquine Treatment.  Intern Med 54:965-970, 2015

Ideguchi M, Kajiwara K, Goto H, Sugimoto K, Nomura S, Ikeda E, Suzuki M: MRI findings and pathological features in early-stage glioblastoma.  J Neurooncol 123:289-97, 2015

Nori S, Okada Y, Nishimura S, Sasaki T, Itakura G, Kobayashi Y, Renault-Mihara F, Shimizu A, Koya I, Yoshida R, Kudoh J, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Nakamura M, Okano H: Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: Oncogenic transformation with epithelial-mesenchymal transition. Stem Cell Reports 10:360-373, 2015


Ishii A, Kimura T, Moritani K, Cui D, Tanaka S, Kawano H, Ikeda E*: Unexpectedly long intravenous and intracardiac extension of a small-sized pulmonary pleomorphic carcinoma. J Thorac Dis 6:E259-263, 2014  [*corresponding author]

Sadahiro H, Yoshikawa K, Ideguchi M, Kajiwara K, Ishii A, Ikeda E, Owada Y, Yasumoto Y, Suzuki M: Pathological features of highly invasive glioma stem cells in a mouse xenograft model. Brain Tumor Pathol 31:77-84, 2014


Takahashi Y, Izumi Y, Kohno M, Ikeda E, Nomori H: Airway administration of vascular endothelial growth factor siRNAs induces transient airspace enlargement in mice.  Int J Med Sci 10:1702-1714, 2013

Murakami T, Kanchiku T, Suzuki H, Imajo Y, Yoshida Y, Nomura H, Cui D, Ishikawa T, Ikeda E, Taguchi T: Anti-interleukin-6 receptor antibody reduces neuropathic pain following spinal cord injury in mice.  Exp Ther Med 6:1194-1198, 2013

Morihiro Y, Yasumoto Y, Vaidyan LK, Sadahiro H, Uchida T, Inamura A, Sharifi K, Ideguchi M, Nomura S, Tokuda N, Kashiwabara S, Ishii A, Ikeda E, Owada Y, Suzuki M: Fatty acid binding protein 7 as a marker of glioma stem cells.  Pathol Int 63: 546-553, 2013

Nakamura Y, Mitani N, Ishii A, Hayashi S, Yujiri T, Ikeda E, Tanizawa Y: Idiopathic pneumonia syndrome with thrombotic microangiopathy-related changes after allogeneic hematopoietic stem cell transplantation.  Int J Hematol 98:496-498, 2013

Inamura A, Adachi Y, Inoue T, He Y, Tokuda N, Nawata T, Shirao S, Nomura S, Fujii M, Ikeda E, Owada Y, Suzuki M: Cooling treatment transiently increases the permeability of brain capillary endothelial cells through translocation of claudin-5.  Neurochem Res 38:1641-1647, 2013

Ishii A, Kawano H, Tanaka S, Yamamoto Y, Nakamoto T, Hirose Y, Yamashita H, Morinaga S, Ikeda E*: Non-sebaceous lymphadenoma of the salivary gland with serous acinic cell differentiation, a first case report in the literature.  Pathol Int 63:272-276, 2013  [*corresponding author]

Okano H, Nakamura M, Yoshida K, Okada Y, Tsuji O, Nori S, Ikeda E, Yamanaka S, Miura K: Steps toward safe cell therapy using induced pluripotent stem cells.  Circ Res 112:523-533, 2013

Takubo K, Nagamatsu G, Kobayashi CI, Nakamura-Ishizu A, Kobayashi H, Ikeda E, Goda N, Rahimi Y, Johnson RS, Soga T, Hirao A, Suematsu M, Suda T: Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.  Cell Stem Cell 12:49-61, 2013


Iriuchishima H, Takubo K, Miyakawa Y, Nakamura-Ishizu A, Miyauchi Y, Fujita N, Miyamoto K, Miyamoto T, Ikeda E, Kizaki M, Nojima Y, Suda T: Neovascular niche for human myeloma cells in immunodeficient mouse bone.  PloS One 7(2):e30557, 2012

Hoshii Y*, Nanbara H, Cui D, Takahashi M, Ikeda E: Immunohistochemical examination of Aκ amyloidosis with antibody against adjacent portion of the carboxy terminus of immunoglobulin kappa light chain.  Med Mol Morphol 45:124-128, 2012  [*corresponding author]


Kawano H*, Tanaka S, Ishii A, Cui D, Eguchi S, Hashimoto O, Ikeda E: Osteoclast-rich undifferentiated carcinoma of the urinary bladder: an immunohistochemical study.  Pathol Res Pract 207:722-728, 2011  [*corresponding author]

Nori S, Okada Y, Yasuda A, Tsuji O, Takahashi Y, Kobayashi Y, Fujiyoshi K, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Yamanaka S, Nakamura M, Okano H: Grafted human-induced pluripotent stem-cell?derived neurospheres promote motor functional recovery after spinal cord injury in mice.  Proc Natl Acad Sci U S A 108:16825-16830, 2011

Ishii A, Hoshii Y, Nakashima T, Umemoto S, Nakamura H, Tanaka N, Matsuzaki M, Ikeda E*: Sarcoidosis with pulmonary hypertension exacerbated by Takayasu-like large vessel vasculitis.  Pathol Int 61:546-550, 2011  [*corresponding author]

Takahashi Y, Izumi Y, Kohno M, Kawamura M, Ikeda E, Nomori H: Airway administration of dexamethasone, 3'-5'-cyclic adenosine monophosphate, and isobutylmethylxanthine facilitates compensatory lung growth in adult mice.  Am J Physiol Lung Cell Mol Physiol 300:L453-461, 2011

Hirose Y, Sasaki H, Miwa T, Ohba S, Ikeda E, Abe M, Ikeda S, Kobayashi M, Kawase T, Hasegawa M, Yoshida K: Whole genome analysis from microdissected tissue revealed adult supratentorial grade II-III gliomas are divided into clinically relevant subgroups by genetic profile.  Neurosurgery 69:376-190, 2011

Takada Y, Gresh L, Bozec A, Ikeda E, Kamiya K, Watanabe M, Kobayashi K, Asano K, Toyama Y, Wagner EF, Matsuo K: Interstitial lung disease induced by gefitinib and toll-like receptor ligands is mediated by Fra-1.  Oncogene 30:3821-32, 2011

Ohba S, Yoshida K, Sugiyama I, Ikeda E, Kawase T: Dural cyst at the foramen magnum.  Neurol Med Chir 51:671-672, 2011

Mutou J, Hirose Y, Ikeda E, Yoshida K, Nakazato Y, Kawase T: Malignant brain tumor with rhabdoid features in an adult.  Neurol Med Chir 51:449-454, 2011


Takubo K, Goda N, Yamada W, Iriuchishima H, Ikeda E, Kubota Y, Shima H, Johnson RS, Hirao A, Suematsu M, Suda T: Regulation of the HIF-1a level is essential for hematopoietic stem cells.  Cell Stem Cell 7:391-402, 2010

Tsuji O, Miura K, Okada Y, Fujiyoshi K, Mukaino M, Nagoshi N, Kitamura K, Kumagai G, Nishino M, Tomisato S, Higashi H, Nagai T, Katoh H, Kohda K, Matsuzaki Y, Yuzaki M, Ikeda E, Toyama Y, Nakamura M, Yamanaka S, Okano H: Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury.  Proc Natl Acad Sci U S A 107:12704-12709, 2010 [Epub 2010 Jul 6]

Takahashi Y, Izumi Y, Kohno M, Kimura T, Kawamura M, Okada Y, Nomori H, Ikeda E*: Thyroid transcription factor 1 influences the early phase of compensatory lung growth in adult mice.  Am J Respir Crit Care Med 181:1397-1406, 2010  [*corresponding author]

Kodama M, Asano K, Oguma T, Kagawa S, Tomomatsu K, Wakaki M, Takihara T, Ueda S, Ohmori N, Ogura H, Miyata J, Tanaka K, Kamiishi N, Fukunaga K, Sayama K, Ikeda E, Miyasho T, Ishizaka A: Strain-specific phenotypes of airway inflammation and bronchial hyperresponsiveness induced by epicutaneous allergen sensitization in BALB/c and C57BL/6 mice.  Int Arch Allergy Immunol 152 Suppl 1:67-74, 2010

Ohba S, Sasaki H, Kimura T, Ikeda E, Kawase T: Clear cell Meningiomas: three case reports with genetic characterization and review of the literature.  Neurosurgery 67:E870-871, 2010

Ohba S, Yoshida K, Hirose Y, Ikeda E, Kawase T: Meningioma of the cerebellopontine angle in identical twins: a case report.  J Neurooncol 98:411-415, 2010

Tanami Y, Ikeda E*, Jinzaki M, Satoh K, Nishiwaki Y, Yamada M, Okada Y, Kuribayashi S: CT attenuation value of coronary atherosclerotic plaques with different tube voltage: an ex vivo study.  J Comput Assist Tomogr 34:58-63, 2010  [*corresponding author]

Mizusawa Y, Kuji N, Tanaka Y, Tanaka M, Ikeda E, Komatsu S, Kato S, Yoshimura Y: Expression of human oocyte-specific linker histone protein and its incorporation into sperm chromatin during fertilization.  Fertil Steril 93:1134-1141, 2010


Takada Y, Ray N, Ikeda E, Kawaguchi T, Kuwahara M, Wagner EF, Matsuo K: Fos proteins suppress dextran sulfate sodium-induced colitis through inhibition of NF-kB J Immunol 184:1014-1021, 2009

Miura K, Okada Y, Aoi T, Okada A, Takahashi K, Okita K, Nakagawa M, Koyanagi M, Tanabe K, Ohnuki M, Ogawa D, Ikeda E, Okano H, Yamanaka S: Variation in the safety of induced pluripotent stem cell lines.  Nat Biotechnol 27:743-745, 2009

Ohba S, Yoshida K, Hirose Y, Ikeda E, Kawase T: Early malignant transformation of a petroclival meningothelial meningioma.  Neurosurg Rev 32:495-499, 2009

Hayashi T, Nagai S, Fujii H, Baba Y, Ikeda E, Kawase T, Koyasu S: Critical roles of NK and CD8+ T cells in central nervous system listeriosis J Immunol 182:6360-6368, 2009

Yamada W, Nagao K, Horikoshi K, Fujikura A, Ikeda E, Inagaki Y, Kakitani M, Tomizuka K, Miyazaki H, Suda T, Takubo K: Craniofacial malformation in R-spondin2 knockout mice.  Biochem Biophys Res Commun 381:453?458, 2009

Ohba S, Yoshida K, Hirose Y, Ikeda E, Nakazato Y, Kawase T: Cerebral tumor with extensive rhabdoid features and a favorable prognosis.  J Neurosurg 111:492-496, 2009

Ogawa D, Okada Y, Nakamura M, Kanemura Y, Okano HJ, Matsuzaki Y, Shimazaki T, Ikeda E, Ito M, Tamiya T, Nagao S, Okano H : Evaluation of human fetal neural stem/progenitor cells as a source for cell replacement therapy for neurological disorders: properties and tumorigenicity after long-term in vitro maintenance.  J Neurosci Res 87:307-317, 2009

Miwa T, Hirose Y, Sasaki H, Ikeda E, Yoshida K, Kawase T: Genetic characterization of adult infratentorial gliomas.  J Neurooncol 91:251-255, 2009

Yamamoto M, Izumi Y, Horinouchi H, Teramura Y, Sakai H, Kohno M, Watanabe M, Kawamura M, Adachi T, Ikeda E, Takeoka S, Tsuchida E, Kobayashi K: Systemic Administration of Hemoglobin Vesicle Elevates Tumor Tissue Oxygen Tension and Modifies Tumor Response to Irradiation.  J Surg Res 151:48-54, 2009

Sakai H, Okamoto M, Ikeda E, Horinouchi H, Kobayashi K, Tsuchida E: Histopathological changes of rat brain after direct injection of Hb-vesicles (artificial oxygen carriers) and neurological impact in an intracerebral hemorrhage model.  J Biomed Mater Res A 90:1107-1119, 2009


Ikeda E*, Takubo K, Kodama T, Okada Y: Brain-specific expression of vascular endothelial growth factor 146 correlates with the blood-brain barrier induction in quail embryo.  Dev Neurosci 30:331-339, 2008  [*corresponding author]

Shiraishi Y, Asano K, Niimi K, Fukunaga K, Wakaki M, Kagyo J, Takihara T, Ueda S, Nakajima T, Oguma T, Suzuki Y, Shiomi T, Sayama K, Kagawa S, Ikeda E, Hirai H, Nagata K, Nakamura M, Miyasho T, Ishizaka A: Cyclooxygenase-2/Prostaglandin D2/CRTH2 pathway mediates double-stranded RNA-induced enhancement of allergic airway inflammation.  J Immunol 180:541-549, 2008


Koto T, Takubo K, Ishida S, Shinoda H, Inoue M, Tsubota K, Okada Y, Ikeda E*: Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells.  Am J Pathol 170:1389-1397, 2007  [*corresponding author]

Mikami S, Hirose Y, Yoshida K, Kawase T, Ohnishi A, Nagashima K, Mukai M, Okada Y, Ikeda E*: Predominant expression of OLIG2 over ID2 in oligodendroglial tumors.   Virchows Arch 450:575-584, 2007  [*corresponding author]

Takahashi S, Hirose Y, Ikeda E, Fukaya R, Kawase T: Chromosome arm 1q gain associated with good response to chemotherapy in a malignant glioma. Case report.  J Neurosurg 106:488-494, 2007

Abe T, Nogawa S, Tanahashi N, Shiraishi J, Ikeda E, Suzuki N: Cerebral pachyleptomeningitis associated with MPO-ANCA induced by PTU therapy.  Internal Medicine 46:247-250, 2007

Ohba S, Yoshida K, Akiyama T, Ikeda E, Kawase T: Lipomatous meningioma.  J Clin Neurosci  14:1003-1006, 2007

Adachi K, Yoshida K, Miwa T, Ikeda E, Kawase T: Olfactory schwannoma.  Acta Neurochir (Wien) 149:605-611, 2007

Koh H, Tasaka S, Hasegawa N, Yamada W, Shimizu M, Nakamura M, Yonemaru M, Ikeda E, Adachi Y, Fujishima S, Yamaguchi K, Ishizaka A: Protective role of vascular endothelial growth factor in endotoxin-induced acute lung injury in mice.  Respir Res 8:60, 2007 (an online journal)

Shimoda M, Hashimoto G, Mochizuki S, Ikeda E, Nagai N, Ishida S, Okada Y: Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells.  J Biol Chem 282:25864-25874, 2007

Shigematsu N, Kitamura N, Saikawa Y, Ikeda E, Fukada J, Kunieda E, Kitagawa Y, Fukuda K, Okada Y, Kubo A: Death related to pleural and pericardial effusions following chemoradiotherapy in a patient with advanced cancers of the esophagus and stomach.  Keio J Med 56:124-129, 2007


Sakai H, Horinouchi H, Yamamoto M, Ikeda E, Takeoka S, Takaori M, Tsuchida E, Kobayashi K: Acute 40 percent exchange-transfusion with hemoglobin-vesicles (HbV) suspended in recombinant human serum albumin solution: degradation of HbV and erythropoiesis in a rat spleen for 2 weeks.  Transfusion. 46:339-347, 2006

Nakanishi K, Matsuo H, Kanai Y, Endou H, Hiroi S, Tominaga S, Mukai M, Ikeda E, Ozeki Y, Aida S, Kawai T: LAT1 expression in normal lung and in atypical adenomatous hyperplasia and adenocarcinoma of the lung.  Virchows Arch 448:142-150, 2006

Nakamura M, Chiba K, Matsumoto M, Ikeda E, Toyama Y: Pleomorphic xanthoastrocytoma of the spinal cord. Case report.  J Neurosurg Spine 5:72-75, 2006

Nakanish K, Kumaki F, Hiroi S, Mukai M, Ikeda E, Kawai T: Mre11 Expression in Atypical Adenomatous Hyperplasia and Adenocarcinoma of the Lung. Arch Pathol Lab Med 130:1330-1334, 2006

Tanaka KF, Ochi N, Hayashi T, Ikeda E, Ikenaka K: Fluoro-Jade: New fluorescent marker of Rosenthal fibers.  Neurosci Lett 407:127-130, 2006


Ikeda E*: Cellular response to tissue hypoxia and its involvement in disease progression.  Pathol Int 55:603-10, 2005  [*corresponding author]

Noda K, Ishida S, Shinoda H, Koto T, Aoki T, Tsubota K, Oguchi Y, Okada Y, Ikeda E*: Hypoxia induces the expression of membrane-type 1 matrix metalloproteinase in retinal glial cells.  Invest Ophthalmol Vis Sci 46:3817-3824, 2005  [*corresponding author]

Shiraishi Y, Asano K, Nakajima T, Oguma T, Suzuki Y, Shiomi T, Sayama K, Niimi K, Wakaki M, Kagyo J, Ikeda E, Hirai H, Yamaguchi K, Ishizaka A: Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor.  J Pharmacol Exp Ther 312:954-960, 2005

Izumi Y, Oyama T, Ikeda E, Kawamura M, Kobayashi K: The acute effects of transthoracic cryoablation on normal lung evaluated in a porcine model.  Ann Thorac Surg 79:318-322, 2005

Nagai N, Noda K, Urano T, Kubota Y, Shinoda H, Koto T, Shinoda K, Inoue M, Shiomi T, Ikeda E, Tsubota K, Suda T, Oike Y, Ishida S: Selective suppression of pathological, but not physiological, retinal neovascularization by blocking angiotensin II type 1 receptor.  Invest Ophthalmol Vis Sci 46:1078-1084, 2005

Urasaki Y, Nori M, Iwata S, Sasaki T, Hosono O, Kawasaki H, Tanaka H, Dang NH, Ikeda E, Morimoto C: Roxithromycin specifically inhibits development of collagen induced arthritis and production of proinflammatory cytokines by human T cells and macrophages.  J Rheumatol 32:1765-1774, 2005

Komiya K, Enomoto H, Inoki I, Okazaki S, Fujita Y, Ikeda E, Ohuchi E, Matsumoto H, Toyama Y, Okada Y: Expression of ADAM15 in rheumatoid synovium: up-regulation by vascular endothelial growth factor and possible implications for angiogenesis.  Arthritis Res Ther 7:R1158-73, 2005

Akiyama T, Ikeda E, Kawase T, Yoshida K: Pseudocapsule formation after gamma knife radiosurgery for trigeminal neurinoma--case report--.  Neurol Med Chir (Tokyo) 45:526-9, 2005

Izumi Y, Tsukada N, Ikeda E, Kawamura M, Kobayashi K: Superficial contact cryoablation attenuates experimentally created lung air leakage.  Cryobiology 51:306-10, 2005


Kotani M, Kotani T, Ishizaka A, Fujishima S, Koh H, Tasaka S, Sawafuji M, Ikeda E, Moriyama K, Kotake Y, Morisaki H, Aikawa N, Ohashi A, Matsushima K, Huang YC, Takeda J: Neutrophil depletion attenuates interleukin-8 production in mild-overstretch ventilated normal rabbit lung.  Crit Care Med 32:514-519, 2004

Sakai H, Masada Y, Horinouchi H, Yamamoto M, Ikeda E, Takeoka S, Kobayashi K, Tsuchida E: Hemoglobin-vesicles suspended in recombinant human serum albumin for resuscitation from hemorrhagic shock in anesthetized rats.  Crit Care Med 32:539-545, 2004

Sakai H, Horinouchi H, Masada Y, Takeoka S, Ikeda E, Takaori M, Kobayashi K, Tsuchida E: Metabolism of hemoglobin-vesicles (artificial oxygen carriers) and their influence on organ functions in a rat model.  Biomaterials 25:4317-25, 2004

Suda K, Shimada A, Ishikawa H, Seki H, Nishibori H, Mori M, Matsumoto H, Ikeda E: A case of breast cancer with predominant cartilaginous and osseous components.  Breast Cancer 11:217-220, 2004

Kohno M, Ishizaka A, Sawafuji M, Koh H, Hirayama Y, Ikeda E, Shiomi T,Ohashi A, Okada Y, Kobayashi K: Hyperoxia-induced emphysematous changes in subacute phase of endotoxin-induced lung injury in rats.  Am J Physiol Lung Cell Mol Physiol 287:L184-190, 2004

Inoue T, Fujishima S, Ikeda E, Yoshie O, Tsukamoto N, Aiso S, Aikawa N, Kubo A, Matsushima K, Yamaguchi K: CCL22 and CCL17 in rat radiation pneumonitis and in human idiopathic pulmonary fibrosis.  Eur Respir J 24:49-56, 2004

Sakai H, Masada Y, Horinouchi H, Ikeda E, Sou K, Takeoka S, Suematsu M, Takaori M, Kobayashi K, Tsuchida E: Physiologic Capacity of Reticuloendothelial System for Degradation of Hemoglobin-Vesicles (Artificial Oxygen Carriers) after Massive Intravenous Doses by Daily Repeated Infusions for 14 days.  J Pharmacol Exp Ther 311:874-884, 2004

Kodama T, Ikeda E, Okada A, Ohtsuka T, Shimoda M, Shiomi T, Yoshida K, Nakada M, Ohuchi E, Okada Y: ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of HB-EGF.  Am J Pathol 165:1743-1753, 2004

Tabuse M, Uchida K, Ueda R, Ikeda E, Kawase T: Jugular foramen papillary meningioma: a case report.  Brain Tumor Pathol 21:143-147, 2004

Goto T, Ishizaka A, Kobayashi F, Kohno M, Sawafuji M, Tasaka S, Ikeda E, Okada Y, Maruyama I, Kobayashi K: Importance of tumor necrosis factor-alpha cleavage process in post-transplantation lung injury in rats.  Am J Respir Crit Care Med 170:1239-1246, 2004

Yoshizu A, Izumi Y, Park S, Sakai H, Takeoka S, Horinouchi H, Ikeda E, Tsuchida E, Kobayashi K: Hemorrhagic shock resuscitation with an artificial oxygen carrier, hemoglobin vesicle, maintains intestinal perfusion and suppresses the increase in plasma tumor necrosis factor-alpha.  ASAIO J 50:458-463, 2004


Noda K, Ishida S, Inoue M, Obata K, Oguchi Y, Okada Y, Ikeda E*: Production and activation of matrix metalloproteinase-2 in proliferative diabetic retinopathy.  Invest Ophthalmol Vis Sci 44:2163-2170, 2003  [*corresponding author]

Enomoto H, Inoki I, Komiya K, Shiomi T, Ikeda E, Obata K, Matsumoto H, Toyama Y, Okada Y: VEGF isoforms and their receptors are expressed in human osteoarthritic cartilage.   Am J Pathol 162:171-181, 2003

Nakanishi K, Kawai T, Kumaki F, Hiroi S, Mukai M, Ikeda E, Koering CE, Gilson E: Expression of mRNAs for telomeric repeat binding factor (TRF)-1 and TRF2 in atypical adenomatous hyperplasia and adenocarcinoma of the lung.  Clin Cancer Res 9:1105-1111, 2003

Miyake-Nishijima R, Iwata S, Saijo S, Kobayashi H, Kobayashi S, Souta-Kuribara A, Hosono O, Kawasaki H, Tanaka H, Ikeda E, Okada Y, Iwakura Y, Morimoto C: Role of Crk-associated substrate lymphocyte type in the pathophysiology of rheumatoid arthritis in tax transgenic mice and in humans.  Arthritis Rheum 48:1890-1900, 2003

Nakanishi K, Kawai T, Kumaki F, Hiroi S, Mukai M, Ikeda E: Survivin expression in atypical adenomatous hyperplasia of the lung.  Am J Clin Pathol 120:712-719, 2003

Watanabe M, Ishizaka A, Ikeda E, Ohashi A, Kobayashi K: Contributions of bronchoscopic microsampling in the supplemental diagnosis of small peripheral lung carcinoma.  Ann Thorac Surg 76:1668-72, 2003

Makino Y, Nakamura H, Ikeda E, Ohnuma K, Yamauchi K, Yabe Y, Poellinger L, Okada Y, Morimoto C, Tanaka H: Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells.  J Immunol 171:6534-6540, 2003


Inoki I, Shiomi T, Hashimoto G, Enomoto H, Nakamura H, Makino K, Ikeda E, TakataS, Kobayashi K, Okada Y:  Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis.  FASEB J 16:219-221, 2002

Takao M, Ghetti B, Hayakawa I, Ikeda E, Fukuuchi Y, Miravalle L, Piccardo P, Murrell JR, Glazier BS, Koto A :  A novel mutation (G217D) in the Presenilin 1 gene in a Japanese family: presenile dementia and parkinsonism are associated with cotton wool plaques in the cortex and striatum.  Acta Neuropathol 104:155-170, 2002

Hashimoto G, Inoki I, Fujii Y, Aoki T, Ikeda E, Okada Y: Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor165.  J Biol Chem 277:36288-36295, 2002

Nakanishi K, Kawai T, Kumaki F, Hirot S, Mukai M, Ikeda E: Expression of human telomerase RNA component and telomerase reverse transcriptase mRNA in atypical adenomatous hyperplasia of the lung.  Hum Pathol 33:697-702, 2002

Yoshida K, Hiraga K, Ishimori H, Katayama M, Kawase T, Ikeda E, Mukai M: Gliofibrous nodule in the cerebello-medullary fissure.  Neuropathology 22:290-293, 2002


Toda M, Iizuka Y, Yu W, Imai T, Ikeda E, Yoshida K, Kawase T, Kawakami Y, Okano H, Uyemura K: Expression of the neural RNA-binding protein Musashi1 in human gliomas.  Glia 34:1-7, 2001

Sakai H, Horinouchi H, Tomiyama K, Ikeda E, Takeoka S, Kobayashi K, Tsuchida E: Hemoglobin-vesicles as oxygen carriers. Influence on phagocytic activity and histopathological changes in reticuloendothelial system.  Am J Pathol 159(3):1079-1088, 2001

Kabe I, Takebayashi T, Nishiwaki Y, Nakajima T, Ikeda E, Saito T, Tanaka S, Miyauchi H, Endo Y, Omae K: Four-week inhalation toxicity study of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123) in guinea pig.  J Occup Health 43:314-320, 2001

Hayashi M, Yajima K, Maruyama H, Matsumoto K, Inokuchi S, Ikeda E:  A patient with diabetes mellitus and severe arterial embolism.  Keio J Med 50:280-90, 2001


Hirose S, Hosoda Y, Furuya S, Otsuki T, Ikeda E* Expression of vascular endothelial growth factor and its receptors correlates closely with formation of the plexiform lesion in human pulmonary hypertension.  Pathol Int 50:472-479, 2000  [*corresponding author]

Ishida S, Shinoda K, Kawashima S, Oguchi Y, Okada Y, Ikeda E*: Co-expression of VEGF receptors VEGF-R2 and neuropilin-1 in proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci 41:1649-1656, 2000  [*corresponding author]

Ikeda M, Hosoda Y, Hirose S, Okada Y, Ikeda E*: Expression of vascular endothelial growth factor isoforms and their receptors Flt-1, KDR, and neuropilin-1 in synovial tissues of rheumatoid arthritis.  J Pathol 191:426-433, 2000  [*corresponding author]

Nakamura M, Fujishima S, Sawafuji M, Ishizaka A, Oguma T, Soejima K, Matsubara H, Tasaka S, Kikuchi K, Kobayashi K, Ikeda E, Sadick M, Hebert CA, Aikawa N, Kanazawa N, Yamaguchi K: Importance of interleukin-8 in the development of reexpansion lung injury in rabbits.  Am J Respir Crit Care Med 161:1030-1036, 2000

Yoshida K, Onozuka S, Kawase T, Ikeda E: Lateral ventricular meningioma encapsulated by the dura-like membrane.  Neuropathology 20:56-59, 2000

Takizawa M, Ohuchi E, Yamanaka H, Nakamura H, Ikeda E, Ghosh P, Okada Y: Production of tissue inhibitor of metalloproteinases-3 is selectively enhanced by calcium pentosan polysulfate in human rheumatoid synovial fibroblasts.  Arthritis Rheum 43:812-820, 2000

Otani A, Takagi H, Oh H, Suzuma K, Matsumura M, Ikeda E, Honda Y: Angiotensin II-stimulated vascular endothelial growth factor expression in bovine retinal pericytes.  Invest Ophthalmol Vis Sci 41:1192-1199, 2000

Watanabe M, Yu S-K, Sawafuji M, Kawamura M, Horinouchi H, Ikeda E, Kobayashi K: Experimental lung transplantation using non-penetrating vascular clips for anastomosis of the pulmonary artery.  Thorac Cardiov Surg 48: 120-122, 2000

Hayashi T, Kuroshima Y, Yoshida K, Kawase T, Ikeda E, Mukai M: Primary osteosarcoma of the sphenoid bone with extensive periosteal extension--case report.  Neurol Med Chir 40: 419-22, 2000

Jinzaki M, Tanimoto A, Mukai M, Ikeda E, Kobayashi S, Yuasa Y, Narimatsu Y, Murai M: Double-phase helical CT of small renal parenchymal neoplasms: correlation with pathologic findings and tumor angiogenesis.  J Comput Assist Tomogr 24: 835-42, 2000


Hosoda Y, Ikeda E: Pathology of spontaneous occlusion of the circle of Willis (cerebrovascular Moyamoya disease).  Neuropathology 19:137-138, 1999

Nakada M, Nakamura H, Ikeda E, Fujimoto N, Yamashita J, Sato H, Seiki M, Okada Y: Expression and tissue localization of membrane-types 1, 2 and 3 matrix metalloproteinases in human astrocytic tumors.  Am J Pathol 154(2):417-428, 1999

Nagamatsu M, Terao S, Misu K, Li M, Hattori N, Ichimura M, Sakai M, Yamamoto H, Watanabe H, Riku S, Ikeda E, Hata J, Oda M, Satake M, Nakamura N, Matsuya S, Hashizume Y, Sobue G: Axonal and perikaryal involvement in chronic inflammatory demyelinating polyneuropathy.  J Neurol Neurosurg Psychiatry  66(6):727-733, 1999

Yoshida K, Kagami H,Shimazaki K, Kondoh A, Ishimori H, Kawase T, Ikeda E: Malignant lymphoma of the cranial vault: analysis of three cases.  Neuropathology 19:283-287, 1999

Matsuo N, Sato S, Ohki H, Momoshima S, Mochida GH, Sasaki G, Ikeda E, Hata J: A two-year-old female with methylmalonic acidemia and progressive low density lesions in the basal ganglia on CT scans.  Keio J Med 48:204-210, 1999


Sasaki H, Yoshida K, Ikeda E, Asou H, Inaba M, Otani M, Kawase T: Expression of neural cell adhesion molecule (NCAM) in astrocytic tumors: an inverse correlation with malignancy.  Cancer 82(10):1921-1931, 1998


Kamio N, Tanaka Y, Mukai M, Ikeda E, Kuramochi S, Fujii M, Hosoda Y: A hybrid carcinoma: adenoid cystic carcinoma and salivary duct carcinoma of the salivary gland. An immunohistochemical study.  Virchows Arch 430:495-500, 1997

Damert A, Ikeda E, Risau W: Activator-protein-1 binding potentiates the hypoxia-inducible factor-1-mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells.  Biochem J  327:419-423, 1997

Hosoda Y, Ikeda E*, Hirose S: Histopathological studies on spontaneous occlusion of the circle of Willis (cerebrovascular Moyamoya disease).  Clin Neurol Neurosurg 99:203-208, 1997  [*corresponding author]


Ikeda E, Flamme I, Risau W: Developing brain cells produce factors capable of inducing the HT7 antigen, a blood-brain barrier-specific molecule, in chick endothelial cells.  Neurosci Lett 209:149-152, 1996


Ikeda E, Achen MG, Breier G, Risau W: Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells.  J Biol Chem 270:19761-19766, 1995

Masuda Y, Kizaki M, Ueno H, Mori S, Takayama N, Muto A, Matsushita H, Ikeda E, Kawai Y, Ikeda Y: Chronic myelogenous leukemia (CML) associated with granulocyte colony-stimulating factor (G-CSF)-producing mesothelioma.  Leukemia 9: 1591-1594, 1995


Ikeda E*, Hosoda Y: Distribution of thrombotic lesions in the cerebral arteries in spontaneous occlusion of the circle of Willis: cerebrovascular moyamoya disease. Clin Neuropathol 12:44-48, 1993  [*corresponding author]

Ikeda E*, Maruyama I, Hosoda Y: Expression of thrombomodulin in patients with spontaneous occlusion of the circlel of Willis.  Stroke 24:657-660, 1993  [*corresponding author]


Ikeda E*, Hosoda Y: Spontaneous occlusion of the circle of Willis (cerebrovascular moyamoya disease); with special reference to its clinicopathological identity.  Brain Dev 14:251-253, 1992  [*corresponding author]


Ikeda E, Hosoda Y: Extracranial vascular changes in so-called "spontaneous occlusion of the circle of Willis".  Neuropathology 4:515-518, 1991

Hosoda Y, Ikeda E: Histopathology of obstructive arterial lesions. Neuropathology 4:519-522,1991

Ikeda E*, Tsutsumi Y, Yoshida H, Yanagi K: Goblet cell carcinoid of the vermiform appendix with ovarian metastasis mimicking mucinous cystadenocarcinoma.  Acta Pathol Jpn 41:455-460. 1991  [*corresponding author]

Ikeda E*: Systemic vascular changes in spontaneous occlusion of the circle of Willis.  Stroke 22:1358-1362, 1991  [*corresponding author]


Tojo T, Okano Y, Hosoda Y, Akizuki M, Onaka A, Suzuki H, Kanazawa M, Goto N, Handa M, Kobayashi Y, Hosoda Y, Ikeda E, Sakaguchi H: A 35-year-old woman with renal failure and pulmonary hemorrhage.  Keio J Med 38:325-347, 1989

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