研究論文

118. Takii R, Fujimoto M, Pandey A, Jaiswal K, Shearwin-Whyatt L, Grutzner F, and Nakai A. HSF1 is required for cellular adaptation to daily temperature fluctuations. Sci. Rep. 14, 21361, 2024, September 12, 2024, DOI: 10.1038/s41598-024-72415-x. [Abstract]

117. Okada M, Fujimoto M, Srivastava P, Pandey A, Takii R, and Nakai A. The Mediator subunit MED12 promotes formation of HSF1 condensates onheat shock response element arrays in heat-shock clles.FEBS Lett. 597 (13), 1702-1717, 2023 (selected as the Editor's Choice)[Abstract]

116. Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, and Nakai A. HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis. Nat. Commun. 13, 4355, 2022. doi 10.1038/s41467-022-32034-4. (featured in a Nature Communications Editors Highlights webpage)[Abstract ]

115. Kose S, Kenichiro K, Watanabe A, Nakai A, Suzuki Y, and Imamoto N. Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response. Life Science Alliance 5 (9), e202101241, 2022. doi.10.26508/lsa.202101241. [Abstract]

114. Srivastava P, Takii R, Okada M, Fujimoto M, and Nakai A. MED12 interacts with the heat shock transcription factor HSF1 and recruits CDK8 to promote the heat shock response in mammalian cells. FEBS Lett. 2021 May 31. doi: 10.1002/1873-3468.14139. [Abstract]

113. Tabara M, Shiraishi K, Takii R, Fujimoto M, Nakai A, and Matsuyama H. Testicular localization of ATF1 and potential function during spermatogenesis. Biol. Reprod. 2021 May 18:ioab099. doi: 10.1093/biolre/ioab099. [Abstract]

112. Liu M, Fan Y, Li D, Han B, Meng Y, Chen F, Liu T, Song Z, Han Y, Huang L, Chang Y, Cao P, Nakai A, and Tan K. Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS-mitochondrial fission-mitophagy axis. Mol. Oncol. 2021 Mar 6. doi: 10.1002/1878-0261.12936. (Molecular Oncology Top-Cited Paper Award)[Abstract]

111. Li D, Liu B, Fan Y, Liu M, Han B, Meng Y, Xu X, Song Z, Liu X, Hao Q, Duan X, Nakai A, Chang Y, Cao P, Tan K. Nuciferine protects against folic acid-induced acute kidney injury by inhibiting ferroptosis. Br. J. Pharmacol. 178, 1182-1199, 2021. [Abstract]

110. Katiyar A, Fujimoto M, Tan K, Kurashima A, Srivastava P, Okada M, Takii R, and Nakai A. HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response. FEBS Open Bio 10 (6), 1135-1148, 2020. (selected as the winner of inaugural 2021 FEBS Open Bio Prize) [Abstract]

109. Takii R, Fujimoto M, Matsumoto M, Srivastava P, Katiyar A, Nakayama KI, and Nakai A. The pericentromeric protein shugoshin 2 cooperates with HSF1 in heat shock response and RNA Pol II recruitment. EMBO J. e102566, 2019. (selected as Cover, introduced in News & Views) [Abstract]

108. Shao J, Han B, Cao P, Zhang B, Liu M, Li D, Zhou N, Hao Q, Duan X, Chang Y-Z, Nakai A, Fan Y, and Tan K. HSF1 phosphorylation by cyclosporin A confers hyperthermia sensitivity through suppression of HSP expression. Biochim. Biophys. Acta Gene Regul. Mech. 1862, 846-857, 2019. [Abstract]

107.Taufiq F, Maharani N, Li P, Kurata Y, Ikeda N, Kuwabara M, Otani N, Miake J, Hasegawa A, Tsuneto M, Shirayoshi Y, Ninomiya H, Saitoh T, Nakai A, Yamamoto K, and Hisatome I. Uric Acid-Induced Enhancements of Kv1.5 Protein Expression and Channel Activity via the Akt-HSF1-Hsp70 Pathway in HL-1 Atrial Myocytes. Circ J. 83, 718-726, 2019.[Abstract]

106. Fujimoto M, Takii R, Katiyar A, Srivastava P, and Nakai A. Poly(ADP-Ribose) Polymerase 1 Promotes the Human Heat Shock Response by Facilitating Heat Shock Transcription Factor 1 Binding to DNA. Mol. Cell. Biol. 38, e00051-18, 2018. [Abstract]

105. Oda T, Sekimoto T, Kurashima K, Fujimoto M, Nakai A, and Yamashita T. Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts. J. Cell Sci. 131, jcs210724, 2018. (selected as Research Highlights)[Abstract]

104. Fujimoto M, Takii R, Takaki E, Katiyar A, Nakato R, Shirahige K, and Nakai A. The HSF1-PARP13-PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis. Nat. Commun. 8, 1638, 2017.[Abstract]

103. Takii R, Fujimoto M, Matsuura Y, Wu F, Oshibe N, Takaki E, Katiyar A, Akashi H, Makino T, Kawata M, and Nakai A. HSF1 and HSF3 cooperatively regulate the heat shock response in lizards. PLoS One 12, e0180776, 2017.[Abstract]

102. Oka S, Shiraishi K, Fujimoto M, Katiyar A, Takii R, Nakai A, and Matsuyama H. Role of heat shock factor 1 in conserving cholesterol transportation in Leydig cell steroidogenesis via steroidogenic acute regulatory protein. Endocrinology 158, 2648-2658, 2017. (selected as Editor's Choice)[Abstract]

101. S. Ishii, M. Torii, A.I. Son, M. Rajendraprasad, Y.M. Morozov, Y.I. Kawasawa, A.C. Salzberg, M. Fujimoto, K. Brennand, A. Nakai, V. Mezger, F. Gage, P. Rakic, and K. Hashimoto-Torii. Variations in brain defects by prenatal alcohol exposure result from cellular mosaicism in the activation of heat shock signaling. Nat. Commun. 8, 15157, 2017. [Abstract]

100. H. Tamura, M. Kawamoto, S. Sato, I. Tamura, R. Maekawa, T. Taketani, H. Aasada, E. Takaki, A. Nakai, R.J. Reiter, and N. Sugino N. Long-term melatonin treatment delays ovarian aging. J. Pineal Res. 62, e12381, 2017. [Abstract]

99. J. Tsuda, K. Sugahara, T. Hori, E. Kanagawa, E. Takaki, M. Fujimoto, A. Nakai, and H. Yamashita. A study of hearing function and histopathologic changes in the cochlea of the type 2 diabetes model Tsumura Suzuki obese diabetes mouse. Acta Otolaryngol. 136, 1097-1106, 2016. [Abstract]

98. E. Mahati, P. Li, Y. Kurata, N. Maharani, I. Nobuhito, S. Sakata, K. Ogura, J. Miake, T. Aiba, W. Shimizu, N. Nakasone, H. Ninomiya, K. Higaki, K. Yamamoto, A. Nakai, Y. Shirayoshi, and I. Hisatome. M3 muscarinic receptor signaling stabilizes a novel mutant human ether-a-go-go-related gene channel protein via phosphorylation of heat shock factor 1 in transfected cells. Circ. J. 80, 2443-2452, 2016. [Abstract]

97. T. Kondo, I, Hisatome, S. Yoshimura, E. Mahati, T. Notsu, P. Li, K. Iitsuka, M. Kato, K. Ogura, J. Miake, T. Aiba, W. Shimizu, Y. Kurata, S. Sakata, N. Nakasone, H. Ninomiya, A. Nakai, K. Higaki, Y. Kawata, Y. Shirayoshi, A. Yoshida, and K. Yamamoto. Characterization of the novel mutant A78T-HERG from a long QT syndrome type 2 patient: Instability of the mutant protein and stabilization by heat shock factor 1. J. Arrhythm. 32, 433-440, 2016. [Abstract]

96. S. Yokoyama, Y. Ohno, T. Egawa, K. Yasuhara, A. Nakai, T. Sugiura, Y. Ohira, T. Yoshioka, M. Okita, T. Origuchi, and K. Goto. Heat shock transcription factor 1-associated expression of slow myosin heavy chain in mouse soleus muscle in response to unloading with or without reloading. Acta Physiol. 217, 325-337, 2016. [Abstract]

95. Y. Nagata, M. Fujimoto, K. Nakamura, N. Isoyama, M. Matsumura, K. Fujikawa, K. Uchiyama, E. Takaki, R. Takii, A. Nakai, and H. Matsuyama. Anti-TNF-α agent infliximab and splenectomy are protective against renal ischemia-reperfusion injury. Transplantation. 100, 1675-1682, 2016. [Abstract]

94. Y. Ohno, T. Egawa, S. Yokoyama, A. Nakai, T. Sugiura, Y. Ohira, T. Yoshioka, and K. Goto. Deficiency of heat shock transcription factor 1 suppresses heat stress-associated increase in slow soleus muscle mass of mice. Acta Physiol. 215, 191-203, 2015. [Abstract]

93. Y. Yamagata, E. Takaki, M. Shinagawa, M. Okada, K. Jozaki, L. Lee, S. Sato, R. Maekawa, T. Taketani, H. Asada, H. Tamura, A. Nakai and N. Sugino. Retinoic acid has the potential to suppress endometriosis development. J. Ovarian Res. 8, 49, 2-015. [Abstract]

92. Saito K, Kukita K, Kutomi G, Okuya K, Asanuma H, Tabeya T, Naishiro Y, Yamamoto M, Takahashi H, Torigoe T, Nakai A, Shinomura Y, Hirata K, Sato N, Tamura Y. Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE. Eur. J. Immunol. 45, 2028-2041, 2015. [Abstract]

91. Y. Kagawa, Y. Yasumoto, K. Sharifi, M. Ebrahimi, A. Islam, H. Miyazaki, Y. Yamamoto, T. Sawada, H. Kishi, S. Kobayashi, M. Maekawa, T. Yoshikawa, E. Takaki, A. Nakai, H. Kogo, T. Fujimoto, and Y. Owada. Fatty acid-binding protein 7 regulates lipid raft formation in astrocytes through expression of caveolin-1. Glia 63, 780-794, 2015. [Abstract]

90. K.Tan, M. Fujimoto, R. Takii, E. Takaki, N. Hayashida, and A. Nakai. Mitokonndorial SSBP1 protects from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity. Nat. Commun. 6, 6580, 2015. [Abstract]

89. R. Takii, M. Fujimoto, K. Tan, E. Takaki, N. Hayashida, K. Shirahige, and A. Nakai. ATF1 modulates the heat shock response by regulating the stress-inducible HSF1-transcription complex. Mol. Cell. Biol. 35, 11-25, 20015. [Abstract]

88.Y. Nakamura, M. Fujimoto, N. Hayashida, R. Takii, E. Takaki, A. Nakai, M. Muto. Heat shock factor 1 is required for migration and invasion of human melanoma in vitro and in vivo. Cancer Lett. 354, 329-335, 2014. [Abstract ]

87. K. Hashimoto-Torii, M. Torii, M. Fujimoto, A. Nakai, R. EI Fatimy, V. Mezger, MJ. Ju, S. Isii, SH. Chao, KJ. Brennand, FH. Gage, P. Rakic. Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders. Neuron 82, 560-572, 2014. [Abstract]

86. Y. Yamagata, K. Nishino, E. Takaki, S. Sato, R. Maekawa, A. Nakai, and N. Sugino. Genome-wide DNA methylation profiling in cultured eutopic and ectopic endometrial stromal cells. PLoS One 9, e83612, 2014. [Abstract ]

85. M. Chuma, N. Sakamoto, A. Nakai, S. Hige, M. Nakanishi, M. Natsuizaka, G. Suda, T. Sho, K. Hatanaka, Y. Matsuno, H. Yokoo, T. Kamiyama, A. Taketomi, G. Fujii, K. Tashiro, Y. Hikiba, M. Fujimoto, M. Asaka, and S. Maeda. Heat shock factor 1 accelerates hepatocellular carcinoma development by activating nuclear factor k B/ mitogen-activated protein kinase. Carcinogenesis 35, 272-281, 2014. [Abstract ]

84. T. Koya, S. Nishizawa, Y. Ohno, A. Goto, A. Ikuita, M. Suzuki, T. Ohira, T. Egawa, A. Nakai, T. Sugiura, Y. Ohira, T. Yoshioka, M. Beppu, and K. Goto. Heat shock transcription factor 1-deficiency attenuates overloading-associated hypertrophy of mouse soleus muscle. PLoS One 8, e77788, 2013. [Abstract ]

83. R. Prakasam, M. Fujimoto, R. Takii, N. Hayashida, E. Takaki, K. Tan, F. Wu, S. Inouye, and A. Nakai. Chicken IL-6 is a heat-shock gene. FEBS Lett. 587, 3541-3547, 2013. [Abstract ]

82. C. Iwai, P. Li, Y. Kurata, Y. Hoshikawa, K. Morikawa, N. Maharani, K. Higaki, T. Sasano, T. Notsu, Y. Ishido, J. Miake, Y. Yamamoto, Y. Shirayoshi, H. Ninomiya, A. Nakai, S. Murata, A. Yoshida, K. Yamamoto, M. Hiraoka, and I. Hisatome. Hsp90 prevents interaction between CHIP and HERG proteins to facilitate maturation of wild-type and mutant HERG proteins. Cardiovasc. Res. 100, 520-528, 2013. [Abstract ]

81. S. Nishizawa, T. Koya, Y. Ohno, A. Goto, A. Ikuita, M. Suzuki, T. Ohira, T. Egawa, A. Nakai, T. Sugiura, Y. Ohira, T. Yoshioka, M. Beppu, and K. Goto. Regeneration of injured skeletal muscle in heat shock transcriptional factor 1-null mice. Physiol. Rep. 1, e00071, 2013. [Abstract ]

80. R. Maekawa, S. Sato, Y. Yamagata, H. Asada, I. Tamura, L. Lee, M. Okada, H. Tamura, E. Takaki, A. Nakai, and N. Sugino. Genome-wide DNA methylation analysis reveals a potential mechanism for the pathogenesis and development of uterine leiomyomas. PLoS One 8, e66632, 2013. [Abstract ]

79. Lennikov, N. Kitaichi, S. Kase, K. Noda, Y. Horie, A. Nakai, S. Ohno, S. Ishida. Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice. Int. J. Mol. Sci., 14, 2175-2189, 2013. [Abstract ]

78. N. Kondo, M. Katsuno, H. Adachi, M. Minamiyama, H. Doi, S. Matsumoto, Y. Miyazaki, M. Iida, G. Tohnai, H. Nakatsuji, S. Ishigaki, Y. Fujioka, H. Watanabe, F. Tanaka, A. Nakai, G. Sobue. Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration. Nat. Commun., 4, 1405, 2013. [Abstract ]

77. R. Akagi, M. Ohno, K. Matsubara, M. Fujimoto, A. Nakai, and S. Inouye. Glutamine protects intestinal barrier function of colon epithelial cells from ethanol by modulating Hsp70 expression. Pharmacology, 91, 104-111, 2013. [Abstract ]

76. M. Fujimoto, E. Takaki, R. Takii, K. Tan, R. Prakasam, N. Hayashida, S. Iemura, T. Natsume, and A. Nakai. RPA Assists HSF1 Access to Nucleosomal DNA by Recruiting Histone Chaperone FACT. Mol. Cell, 48, 182-194, 2012. [Abstract]

75. M. Kubo, T.-S. Li, H. Kurazumi, Y. Takemoto, M. Ohshima, Y. Yamamoto, A. Nishimoto, A. Mikamo, M. Fujimoto, A. Nakai, K. Hamano. Heat shock factor 1 contributes to ischemia-induced angiogenesis by regulating the mobilization and recruitment of bone marrow stem/progenitor cells. PLoS One 7, e37934, 2012. [Abstract]

74. H. Ma, H. Gong, Z. Chen, Y. Liang, J. Yuan, G. Zhang, J. Wu, Y. Ye, C. Yang, A. Nakai, I. Komuro, J. Ge, Y. Zou. Association of Stat3 with HSF1 plays a critical role in G-CSF-induced cardio-protection against ischemia/reperfusion injury. J. Mol. Cell. Cardiol., 52, 1282-1290, 2012. [Abstract]

73. T. Nakamoto, T. Mikuriya, K. Sugahara, Y. Hirose, T. Hashimoto, H. Shimogori, R. Takii, A. Nakai, H. Yamashita. Geranylgeranylacetone suppresses noise-induced expression of proinflammatory cytokines in the cochlea. Auris Nasus Larynx 39, 270-274, 2012. [Abstract ]

72. Y. Zou, J. Li, H. Ma, H. Jiang, J. Yuan, H. Gong, Y. Liang, A. Guan, J. Wu, L. Li, N. Zhou, Y. Niu, A. Sun, A. Nakai, P. Wang, H. Takano, I. Komura, J. Ge. Heat shock transcription factor 1 protects heat after pressure overload through promoting myocardial angiogenesis in male mice. J. Mol. Cell. Cardiol., 51, 821-829, 2011. [Abstract]

71. K. Yasuhara, Y. Ohno, A. Kojima, K. Uehara, M. Beppu, T. Sugiura, M. Fujimoto, A. Nakai, Y. Ohira, T. Yoshioka, K. Goto. Absence of heat shock transcription factor 1 retards the regrowth of atrophied soleus muscle in mice. J. Applied Physiol., 111, 1142-1149, 2011. [Abstract]

70. T. Shinkawa, K. Tan, M. Fujimoto, N. Hayashida, K. Yamamoto, E. Takaki, R. Takii, R. Prakasam, S. Inouye, V. Mezger, and A. Nakai. Heat shock factor 2 is required for maintaining proteostasis against febrile range thermal stress and polyglutamine aggregation. Mol. Biol. Cell 22, 3571-3583, 2011. [Abstract](A highlight from MBoC selection)

69. M. Hatori, T. Hirota, M. Iitsuka, N. Kurabayashi, S. Haraguchi, K. Kokame, R. Sato, A. Nakai, T. Miyata, K. Tsutsui, and Y. Fukada. Light-dependent and circadian clock-regulated activation of SREBP, XBP1 and HSF pathways in the pineal gland. Proc. Natl. Acad. Sci. USA 108, 4864-4869, 2011. [Abstract]

68. Y. K. Ting, K. Morikawa, Y. Kurata, P.L. Li, U. Bahrudin, M. Kato, J. Miake, Y. Yamamoto, A. Yoshida, M. Murata, T. Inoue, A. Nakai, G. Shiota, K. Higaki, H. Ninomiya, Y. Shirayoshi, I. Hisatome. Transcriptional activation of SAP97 by HSF-1 stabilizes Kv1.5 in HL-1 cells. Brit. J. Pharmacol. 162, 1832-1842, 2011. [Abstract]

67. P. Li, H. Ninomiya, Y. Kurata, M. Kato, J. Miake, Y. Yamamoto, O. Igawa, A. Nakai, K. Higaki, F. Toyoda, J. Wu, M. Horie, H. Matsuura, A. Yoshida, Y. Shirayoshi, M. Hiraoka, and I. Hisatome. Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability. Circ. Res. 108, 458-468, 2011. [Abstract ]

61. R. Takii, S. Inouye, M. Fujimoto, T. Nakamura, T. Shinkawa, R. Prakasam, K. Tan, N. Hayashida, H. Ichikawa, T. Hai, and A. Nakai. Heat shock transcription factor 1 inhibits expression of IL-6 through inducing activation transcription factor 3. J. Immunol. 184, 1041-1048, 2010. [Abstract ]

60. M. Fujimoto, N. Hayashida, T. Kato, K. Oshima, T. Shinkawa, R. Prakasam, K. Tan, S. Inouye, R. Takii and A. Nakai. A novel mouse HSF3 has the potential to activate nonclassical heat-shock genes during heat shock. Mol. Biol. Cell. 21, 106-116, 2010. (A highlight from MBC selection) [Abstract ]

59. M. Adachi, Y. Liu, K. Fujii, S.K. Calderwood, A. Nakai, K. Imai, and Y. Shinomura. Oxidative stress impairs the heat stress response and delays unfolded protein recovery. PLoS One 4, e7719, 2009. [Abstract]

58. S. Suemasu, K. Tanaka, T. Namba, T. Ishihara, T. Katsu, M. Fujimoto, H. Adachi, G. Sobue, K. Takeuchi, A. Nakai, and Mizushima, T. Role for HSP70 in protecting against indomethacin-induced gastric lesions. J. Biol. Chem. 284,19705-19715, 2009. [Abstract]

57. Y. Tateishi, M. Ariyoshi, R. Igarashi, H. Hara, K. Mizuguchi, A. Seto, A. Nakai, T. Kokubo, H. Tochio, and M. Shirakawa. Molecular basis for SUMOylation-dependent regulation of DNA binding activity of Heat Shock Factor 2. J. Biol. Chem. 284, 2435-2447, 2009. [Abstract]

56. M. Fujimoto, I. Oshima, T. Shinkawa, B. Wang, S. Inouye, N. Hayashida, R.Takii, and A. Nakai. Analysis of HSF4 binding regions reveals its necessity for gene regulation during development and heat shock response in mouselenses. J. Biol. Chem. 283: 29961-29970, 2008. [Abstract]

55. Y. Hirota, Y. Kurata, M. Kato, T. Notsu, S. Koshida, T. Inoue, Y. Kawata, J. Miake, U. Bahrudin, P. Li, Y. Hoshikawa, Y. Yamamoto, O. Igawa, Y. Shirayoshi, A. Nakai, H. Ninomiya, K. Higaki, M. Hiraoka, and I. Hisatome. Functional stabilization of Kv1.5 protein by Hsp70 in mammalian cell lines. Biochem. Biophy. Res. Commun. 372, 469-474, 2008. [Abstract]

54. C. Nakamura, Y. Nakamura, T. Gondo, E. Takaki, M. Fujimoto, S. Inouye, A. Nakai, and M. Muto. HSF1 is important for protection of mouse epidermal cells against heat stress. The Bulletin of the Yamaguchi Medical School, 1-2: 1-8, 2008.

53. T. Mikuriya, K. Sugahara, K. Sugimoto, M. Fujimoto, T. Takemoto, M.Hashimoto, Y. Hirose, H. Shimogori, N. Hayashida, S. Inouye, A. Nakai, H.Yamashita. Attenuation of progressive hearing loss in a model of age-relatedhearing loss by a heat shock protein inducer, Geranylgeranylacetone. Brain Res. 1212 : 9-17, 2008. [Abstract]

52. Y. Hirota, M. Kato, T. Notsu, S. Koshida, T. Inoue, Y. Kawata, J. Miake, U.Bahrudin, P. Li, Y. Hoshikawa, Y. Yamamoto, O. Igawa, Y. Shirayoshi, A.Nakai, H. Ninomiya, K. Higaki, M. Hiraoka, and I. Hisatome. Functionalstabilization of Kv1.5 protein by Hsp70 in mammalian cell lines. Biochem. Biophy. Res. Commun. 372: 469-474, 2008. [Abstract]

51. E. Takaki, M. Fujimoto, T Nakahari, S. Yonemura, Y. Miyata, N. Hayashida, K. Yamamoto, R.B. Vallee, T. Mikuriya, K. Sugahara, H. Yamashita, S. Inouye, and A. Nakai. Heat shock transcription factor 1 is required for maintenance of ciliary beating in mice. J. Biol. Chem. 282: 37285-37292, 2007. [Abstract]

50. S. Inouye, M. Fujimot, T, Nakamura, E. Takaki, N. Hayashida, and A. Nakai. HSF1 opens chromatin structure of IL-6 promoter to facilitate binding of an activator or a repressor. J. Biol. Chem. 282, 33210-33217, 2007. [Abstract]

49. K. Tanaka, T. Namba, Y. Arai, M. Fujimoto, H. Adachi, G. Sobue, K. Takeuchi, A. Nakai, and T. Mizushima. Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis. J. Biol. Chem. 282: 23240-23252, 2007. [Abstract]

48. H. Kitamei, N. Kitaichi, K. Yoshida, A. Nakai, M. Fujimoto, M. Kitamura, K. Iwabuchi, A. Miyazaki, K. Namba, S. Ohno, and K. Onoe. Association of heat shock protein 70 induction and the amelioration of experimental autoimmune uveoretinitis in mice. Immunobiology 212: 11-18, 2007.

47. K. Tanaka, S. Tsutsumi, Y. Arai, T. Hoshino, K. Suzuki, E. Takai, T. Itoh, K. Takeuchi, A. Nakai, and T. Mizushima. Genetic evidence for a protective role of heat shock factor 1 against irritant-induced gastric lesions. Mol. Pharmacol. 71: 985-993, 2007.

46. M. Otaka, S. Yamamoto, K. Ogasawara, Y. Takaoka, S. Noguchi, T. Miyazaki, A. Nakai, M. Odashima, T. Matsuhashi, S. Watanabe, and H. Itoh. The induction mechanism of the molecular chaperone HSP70 in the gastric mucosa by Geranylgeranylacetone (HSP-inducer). Biochem. Biophy. Res. Commun. 353: 399-404, 2007.

45. T. Uchiyama, H. Atsuta, T. Utsugi, M. Oguro, A. Hasegawa, T. Nakamura, A. Nakai, M. Nakata, I. Maruyama, H. Tomura, F. Okajima, S. Tomono, S. Kawazu, R. Nagai, M. Kurabayashi. HSF1 and constitutively active HSF1 improve vascular endothelial function (heat shock proteins improve vascular endothelial function). Atherosclerosis 190: 321-329, 2007.

44. M. Sakamoto, T. Minamino, H. Toko, Y. Kayama, Y. Zou, M. Sano, E. Takaki, T. Aoyagi, K. Tojo, N. Tajima, A. Nakai, H. Aburatani, and I. Komuro. Upregulation of Heat Shock Transcription Factor 1 Plays a Critical Role in Adaptive Cardiac Hypertrophy. Circ. Res. 99: 1411-1418, 2006.

43. N. Hayashida, S. Inouye, M. Fujimoto, Y. Tanaka, H. Izu, E. Takaki, H. Ichikawa, J. Rho and A. Nakai. A novel HSF1-mediated death pathway that is suppressed by heat shock proteins. EMBO J. 25: 4773-4783, 2006.

42. T. Uchiyama, H. Atsuta, T. Utsugi, Y. Oyama, T. Nakamura, A. Nakai, M. Nakata, I. Maruyama, H. Tomura, F. Okajima, S. Tomono, S. Kawazu, R. Nagai, M. Kurabayashi. Simvastatin induces heat shock factor 1 in vascular endothelial cells. Atherosclerosis 188: 265-273, 2006.

41. F. Shinozaki, M. Minami, T. Chiba, M. suzuki, K. Yoshimatsu, Y. Ichikawa, K. Terasawa, Y. Emori, K. Matsumoto, T. Kurosaki, A. Nakai, K. Tanaka, and Y. Minami. Depletion of HSP90 induces multiple defects in B cell receptor signaling. J. Biol. Chem. 281: 16361-16369, 2006.

40. E. Takaki, M. Fujimoto, K. Sugahara, T. Nakahari, S. Yonemura, Y. Tanaka, N. Hayashida, S. Inouye, T. Takemoto, H. Yamashita and A. Nakai.　Maintenance of olfactory neurogenesis requires HSF1, a major heat shock transcription factor in mice. J. Biol. Chem. 281: 4931-4937, 2006.

39. V. Hietakangas, J. Anckar, H. Blomster, M. Fujimoto, J. J. Palvimo, A. Nakai, and L. Sistonen. PDSM, a motif for phosphorylation-dependent SUMO modification. Proc. Natl. Acad. Sci. USA 103: 45-50, 2006.

38. T. Mikuriya, K. Sugahara, T. Takemoto, K. Tanaka, K. Takeno, H. Shimogori, A. Nakai, and H. Yamashita. Geranylgeranylacetone, a heat shock protein inducer, prevents acoustic injury in the guinea pig. Brain Res. 1065: 107-114, 2005.

37. M. Fujimoto, E. Takaki, T. Hayashi, Y. Kitaura, Y. Tanaka, S. Inouye, and A. Nakai. Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models. J. Biol. Chem. 280: 34908-34916, 2005.

36. M. Fujimoto, H. Izu, K. Seki, K. Fukuda, T. Nishida, S. Yamada, K. Kato, S. Yonemura, S. Inouye, and A. Nakai. HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J. 23, 4297-4306, 2004.

35. S. Inouye, H. Izu, E. Takaki, H. Suzuki, M. Shirai, Y. Yokota, H. Ichikawa, M. Fujimoto, and A. Nakai. Impaired IgG production in mice deficient for heat shock transcription factor 1. J. Biol. Chem. 279, 38701-38709, 2004.

34. K. Katsuki, M. Fujimoto, X.-Y. Zhang, H. Izu, E. Takaki, Y. Tanizawa, S. Inouye, and A. Nakai. Feeding induces expression of heat shock proteins that reduce oxidative stress. FEBS Letter 571: 187-191, 2004.

33. Y. Katoh, M. Fujimoto, K. Nakamura, S. Inouye, K. Sugahara, H. Izu, and A. Nakai. Hsp25, a member of the Hsp30 family, promotes inclusion formation in response to stress. FEBS Letter 565: 28-32, 2004.

32. H. Izu, S. Inouye, M. Fujimoto, K. Shiraishi, K. Naitoh,Sugahara, and A. Nakai.HSF1 is involved in quality control mechanisms in male germ cells. Biol. Reprod. 70: 18-24, 2004.

31. Y. Zou, W. Zhu, M. Sakamoto, Y. Qin, H. Akazawa, H. Toko, M. Mizukami, N. Takeda, T. Minamino, H. Takano, T. Nagai, A. Nakai, and I. Komuro. Heat Shock Transcription Factor 1 Protects Cardiomyocytes From Ischemia/Reperfusion Injury. Circulation 108: 3024-3030, 2003.

30. W. Widlak, K. Benedyk, N. Vydra, M. Glowala, D. Lcieglilska, E. Malusecka, A. Nakai, and Z. Krawczyk. Expression of a constitutively active mutant of heat shock factor 1 under the control of testis-specific hst70 gene promoter in transgenic mice induces degeneration of seminiferous epithelium. Acta Bioch. Pol., 50: 535-541, 2003.

29. K. Sugahara, S. Inouye, H. Izu, Y. Katoh, K. Katsuki, T. Takemoto, H. Shimogori, H. Yamashita, and A. Nakai. Heat shock transcription factor HSF1 is required for survival of sensory hair cells against acoustic overexposure. Hearing Res., 182: 88-96, 2003.

28. S. Inouye, K. Katsuki, H. Izu, M. Fujimoto, K. Sugahara, S. Yamada, Y. Shinkai, Y. Oka, Y. Katoh, and A. Nakai. Activation of heat shock genes is not necessary for heat shock transcription factor 1 to protect cell death against a single exposure to high temperatures. Mol. Cell. Biol., 23: 5882-5895, 2003.

27. J. M. Shallom, A. L. D. Carlo, D. Ko, L. M. Penafiel, A. Nakai, and T. A. Litovitz. Microwave exposure induces Hsp70 and confers protection against hypoxia in chick embryos. J. Cell. Biochem. 86: 490-496, 2002.

26. J. Nishizawa, A. Nakai, M. Komeda, T. Ban, and K. Nagata. Increased preload directly induces the activation of heat shock transcription factor 1 in the left ventricular overloaded heart. Cardiovasc. Res. 55: 341-348, 2002.

25. A. Nakai, and T. Ishikawa. Cell cycle transition on stress conditions controlled by vertebrate heat shock factors. EMBO J. 20: 2885-2895, 2001.

24. A. Nakai, and T. Ishikawa. A nuclear localization signal is essential for stress-induced dimer-to-trimer transition of heat shock transcription factor 3. J. Biol. Chem. 275: 34665-34671, 2000.

23. J. Tanikawa, E. Ichikawa-Iwata, C. Kanei-Ishii, A. Nakai, S. Matsuzawa, J. C. Reed, and S. Ishii. p53 suppresses the c-myb-induced activation of heat shock transcription factor 3. J. Biol. Chem. 275: 15578-15585, 2000.

22. A. Nakai, M. Suzuki, and M. Tanabe. Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1. EMBO J. 19: 1545-1554, 2000.

21. M. Tanabe, N. Sasai, K. Nagata, X. D. Liu, Phillip C. C. Liu, Dennis J. Thiele, and Akira Nakai. The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing. J. Biol. Chem. 274: 27845-27856, 1999.

20. Yoshinori Kawazoe, Masako Tanabe, Noriaki Sasai, Kazuhiro Nagata, and Akira Nakai. HSF3 is a major heat shock responsive factor during chicken embryonic development. Eur. J. Biochem. 265: 688-697, 1999.

19. Yoshinori Kawazoe, Masako Tanabe, and Akira Nakai. Ubiquitous and cell-specific members of the avian small heat shock protein family. FEBS Letter 455: 271-275, 1999.

18. Junichiro Nishizawa, Akira Nakai, Katsuhiko Matsuda, Toshio Ban, and Kazuhiro Nagata. Reactive oxygen species play an important role in the activation of heat shock factor 1 in ischemia-reperfused heart. Circulation 99: 934-941, 1999.

17. Yoshinori Kawazoe, Akira Nakai, Masako Tanabe and Kazuhiro Nagata. Proteasone inhibition leads to the activation of all members of the heat-shock-factor family. Eur. J. Biochem. 255: 356-362, 1998.

16. Masako Tanabe, Yoshinori Kawazoe, Shunichi Takeda, Richard I. Morimoto, Kazuhiro Nagata and Akira Nakai. Disruption of theHSF3 gene results in the severe reduction of heat shock gene expression and loss of thermotolerance. EMBO J. 17: 1750-1758, 1998.

15. Naoki Watanabe, Naoki Tsuji, Shinichiro Akiyama, Hiroyoshi Sasaki, Tetsuro Okamoto, Daisuke Kobayashi, Tsutomu Sato, Tsukasa Hagino, Naofumi Yamauchi, Yoshiro Niitsu, Akira Nakai and Kazuhiro Nagata. Induction of heat shock protein 72 synthesis by endogenous tumor necrosis factor via enhancement of the heat shock element-binding activity of heat shock factor 1. Eur. J. Immunol. 27: 2830-2834, 1997.

14. Chie Kanei-Ishii, Jun Tanikawa, Akira Nakai, Richard I. Morimoto and Shunsuke Ishii. Activation of heat shock transcription factor 3 by c-myb in the absence of cellular stress. Science 277: 246-248, 1997.

13. Masako Tanabe, Akira Nakai, Yoshinori Kawazoe and Kazuhiro Nagata. Different Thresholds in the response of two heat shock transcription factors, HSF1 and HSF3. J. Biol. Chem. 272: 15389-15395, 1997.

12. Tetsuo Noguchi , Kazuo Chin, Motoharu Ohi, Hideo Kita, Naoki Otsuka, Tomomasa Tsuboi, Mamoru Satoh, Akira Nakai, Takesi Kuno and Kazuhiro Nagata. Heat shock protein 72 level decreases during sleep in patients with obstructive sleep apnea syndrome. American J. Respir. Crit. Care Med. 155: 1316-1322, 1997.

11. Akira Nakai, Masako Tanabe, Yoshinori Kawazoe, Johji Inazawa, Richard I. Morimoto and Kazuhiro Nagata. HSF4, a new member of the human heat shock factor gene family which lacks properties of a transcriptional activator. Mol. Cell. Biol. 17: 469-481, 1997.

10. Talal S.H. El-Thaher, Alex F. Drake, Shinichi Yokota, Akira Nakai, Kazuhiro Nagata and Andrew D. Miller. The pH-dependent, ATP-independent interaction of collagen specific serpin/stress proten HSP47. Protein and Peptide Letters 13: 1-8, 1996.

9. Junichiro Nishizawa, Akira Nakai, Toshio Higashi, Masako Tanabe, Shinichi Nomoto, Katsuhiko Matsuda, Toshihiko Ban and Kazuhiro Nagata. Reperfusion causes significant activation of heat shock transcription factor 1 in ischemic rat heart. Circulation 94: 2185-2192, 1996.

8. Joseph W. Davis, Talal S.H. El-Thaher, Akira Nakai, Kazuhiro Nagata and Andrew D. Miller. Modeling the three-dimensional structure of serpin/molecular chaperone HSP47. Bioorganic Chemistry 23: 427-438, 1995.

7. Kunihiko Yasuda, Akira Nakai, Takumi Hatayama and Kazuhiro Nagata. Cloning and expression of murine high molecular mass heat shock proteins, HSP105. J. Biol. Chem. 270: 29718-29723, 1995.

6. Akira Nakai, Yoshinori Kawazoe, Masako Tanabe, Kazuhiro Nagata and Richard I. Morimoto. The DNA binding properties of two heat shock factors, HSF1 and HSF3, are induced in the avian erythroblast cell line HD6. Mol. Cell. Biol. 15: 5268-5278, 1995.

5. Toshio Higashi, Akira Nakai, Yoshihiko Uemura, Haruhiko Kikuchi and Kazuhiro Nagata. Activation of heat shock factor 1 in the rat brain during cerebral ischemia and after heat shock. Mol. Brain Res. 34: 262-270, 1995.

4. Naoko Nagai, Akira Nakai and Kazuhiro Nagata. Quercetin supresses heat shock response by down regulation of HSF1. Biochem. Biophys. Res. Commun. 208 (3): 1099-1105, 1995.

3. Akira Nakai, Toshio Kawatani, Shinji Ohi, Hironaka Kawasaki, Tamotsu Yoshimori, Yutaka Tashiro, Yoshihiko Miyata, Ichiro Yahara, Mamoru Satoh and Kazuhiro Nagata. Expression and phosphorylation of BiP/GRP78, a molecular chaperone in the endoplasmic reticulum, during the differentiation of a mouse myeloblastic cell line. Cell Struct. Funct. 20 (1): 33-39, 1995.

2. Mamoru Satoh, Akira Nakai, Yoshihiro Sokawa, Kazunori Hirayoshi and Kazuhiro Nagata. Modulation of the phosphorylation of glucose-regulated protein, grp78, by transformation and inhibition of glycosylation. Exp. Cell Res. 205: 76-83, 1993.

1. Akira Nakai and Richard I. Morimoto. Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway. Mol. Cell. Biol. 13: 1983-1997, 1993.